PREPARATIVE MEDIA & COMPLETE HPLC COLUMN PORTFOLIO

From Analytical Screening to 25-Ton Industrial Scale — Without Method Drift.

Engineered organo-inorganic XP hybrid silica (pH 1–12) with patented tri-bonding chemistry. WePure delivers Waters-grade resolution, 40-hr 0.1M NaOH CIP resilience, and dedicated multi-ton capacity backed by US FDA DMF Type II registration.

25 Tons Annual Silica Output
FDA DMF Type II Registered
40h CIP in 0.1M NaOH (≥95%)
WePure three core technology platforms: porous microsphere synthesis, surface bonding modification, column packing
25 Tons / Yr
Silica Media Capacity (40-Mu Base)
FDA DMF #
US FDA Drug Master File Type II
1.7 – 100 µm
Complete Spectrum (Identical Chemistry)
1 – 3 Days
Rapid Sample Dispatch Worldwide

Full-Spectrum HPLC, UHPLC & Preparative Column Ecosystem

Precision-packed columns and hardware engineered for analytical method development, biomolecule separation, and industrial scale-up.

MicroPulite Analytical Columns

MicroPulite® Series (1.7–5 µm)

Ultra-pure spherical silica & hybrid columns for high-throughput screening, wide pH, and polar retention.

Gold C18PlatinumXP (pH 1-12)PHS XPPerfect T3
BioPulite Bioseparation Columns

BioPulite® Bioseparation

Dedicated wide-pore columns (150Å/300Å) for GLP-1 (Semaglutide), recombinant insulin, oligonucleotides & ADCs.

XP Protein tC18XP Protein tC4RP18 PlusLoading: 10g/L
PrePulite Preparative Media & Columns

PrePulite® Preparative Media

Semi-prep columns (10–50mm ID) and 25-ton DAC bulk media (10–100 µm) with identical selectivity to analytical lines.

XP Hybrid PrepPolyPulite RP-125-Ton OutputDAC 20+ Cycles
WeChromlite Guard Columns & In-line Filters

WeChromlite® Guard System

Direct-connect analytical guard holders (18,000 psi UPLC rating) and in-line filters to triple column lifespan.

18,000 psiTool-FreeSemi-Prep G100/1900.2µm Filters

Patented Core Technologies & Structural Verification

Empirical laboratory verification of particle morphology, mechanical strength, and alkaline tolerance.

SEM Micrograph Monodisperse Silica

SEM Micrograph Morphology

Uniform, interconnected 3D pore channels ensuring high column efficiency and optimal mass transfer.

Narrow Particle Size Distribution

Tight Particle Control (CV <5%)

Strict batch-to-batch particle uniformity guarantees consistent backpressure and zero bed voiding.

40h Alkaline CIP Stability

40-Hr 0.1M NaOH CIP Resilience

XP hybrid matrix maintains ≥95% efficiency after 40 hours in caustic wash (pH 1–12).

20+ DAC Repacking Cycles

Zero-Fines in 20+ DAC Repacks

Rigid hybrid matrix withstands repetitive axial packing pressure without generating particle fines.

Proven Commercial Chromatogram Case Studies

Real-world purification data from pharmaceutical production campaigns.

Recombinant Human Insulin Preparative Purification

Insulin Preparative Chromatogram
Crude
97.31%
Final Purity
99.89%
Single Imp.
≤0.09%
Yield
87.83%

Semaglutide (GLP-1) API High-Yield Purification

Semaglutide Preparative Chromatogram
Crude
77.09%
Final Purity
99.77%
Single Imp.
≤0.09%
Loading
10 g/L

Request Your Validation Kit & Sample Column

Includes 1x MicroPulite® Analytical Screening Column (Free) OR 5g PrePulite® XP Bulk Media + Full GLP-1 Scale-Up Whitepaper & FDA DMF Package.

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Our technical director will review your column requirements and arrange complimentary sample dispatch within 24 hours.